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Moreover, the indole core is substituted at R3 having a carbonyl group that is also bonded to some napthalene moeity. Napthalene can be a bicyclic construction of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it to be a ketone. JWH-018 is undoubtedly an analog of THJ-018, where the core indazole framework is substituted using an indole base. Pharmacology
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substituted naphthoyl derivatives inside the naphthoylindole collection, having a higher binding affinity at CB1
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